| Y. Li, E. Roth, V. Agrawal, A. Eshein, J. Frederick, L. Almassalha, A.R. Shim, R. Bleher, V.P. Dravid, and V. Backman | “Analysis of three-dimensional chromatin packing domains by chromatin scanning transmission electron microscopy: ChromSTEM”, Scientific Reports, 12 | 2022 |
| S. Yadav, R. Virk, C.H. Chung, D. Van Derway, D. Chen, K. Burdett, H. Gao, Z. Zeng, M. Ranjan, G. Cottone, X. Xuei, S. Chandrasekaran, V. Backman, R. Chatterton, S.A. Khan, and S.E. Clare | “Lipid exposure of non-transformed mammary cells activates gene expression signatures associated with ER-negative breast cancer via chromatin remodeling”, npj Breast Cancer, 8(59) https://doi.org/10.1038/s41523-022-00422-0
| 2022 |
| A. Shim, K. Huang, V. Backman and I. Szleifer | “Chromatin as self-returning walks: from population to single-cell, and back”, Biophysical Reports, 2(1) https://doi.org/10.1016/j.bpr.2021.100042
| 2022 |
| Z. Ji, X. Wang, J. Frederick, H. Wang, S. Hui and V. Backman | “Spike-in normalization for single-cell RNA-seq reveals dynamic global transcriptional activity mediating anti-cancer drug response", NAR Genomics and Bioinformatics, 3(2) doi: 10.1093/nargab/lqab054
| 2021 |
| T.D. Swain, S. Lax, J. Gilbert, V. Backman and L. Marcelino | "A phylogeny-informed analysis of the global coral-symbiodiniceae interaction network reveals that traits correlated with thermal bleaching are specific to symbiont transmission mode”, mSystems, 10.1128/mSystems.00266-21
| 2021 |
| S. Prasad, A. Rankine, T. Prasad, P. Song, M.E. Dokukin, N. Makarova, V. Backman, and I. Sokolov | "Atomic force microscopy detects the difference in cancer cells of different neoplastic aggressiveness via machine learning”, Advanced NanoBioMed Research, doi: 10.1002/anbr.202000116
| 2021 |
| O. Butger, Y. Li, A. Wolters, V. Agrawal, A. Dravid, A. Chang, J. Hardillo, B. Giepmans, R. de Jong, A. Amelink, V. Backman and D.J. Robinson | "Early upper aerodigestive tract cancer detection using electron microscopy to reveal chromatin packing alterations in buccal mucosa cells”, Microscopy & Microanalysis, doi: 10.1017/S1431927621000507. PMC8939050
| 2021 |
| A. Eid, J. Winkelmann, A. Taflove, and V. Backman | “Origins of subdiffractional contrast in optical coherence tomography”, Biomedical Optics Express, 12(6): 3630–3642
| 2021 |
| Y. Li, A. Eshein, R.K.A. Virk, A. Eid, W. Wu, J. Frederick, D. VanDerway, S. Gladstein, K. Huang, N.M. Anthony, G.M. Bauer, X. Zhou, V. Agrawal, E. Pujadas, G. Esteve, J.E. Chandler, R. Bleher, J. de Pablo, I. Szleifer, V. Dravid, L.M. Almassalha, V. Backman | “Nanoscale Chromatin Imaging and Analysis (nano-ChIA) platform bridges 4-D chromatin organization with molecular function,” Science Advances 7, eabe4310 | 2021 |
| A. Daneshkhah, V. Agrawal, A. Eshein, H. Subramanian, H.K. Roy, and V. Backman | “Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients,” Aging Clinical and Experimental Research, doi: 10.1007/s40520-020-01677-y | 2020 |
| A. Eid, A. Eshein, Y. Li, R. Virk, D. VanDerway, A. Taflove and V. Backman | “Characterizing chromatin packing scaling in whole nuclei using interferometric microscopy ”, Optics Letters, 45(17) 4810-4813 (2020), | 2020 |
| K. Huang, Y. Li, A.R. Shim, R.J. Nap, V. Agrawal, R.K.A. Virk, A. Eshein, L.M. Almassalha, V. Backman and I. Szleifer | “Physical and data structure of 3D genome”, Science Advances, 6(2), doi: 10.1126/sciadv.aay4055 (2020) | 2020 |
| R.K.A. Virk, W. Wu, L. M. Almassalha, G. M. Wodarcyk, Y. Li, D. VanDerway, J. Frederick, D. Zhang, A. Eshein, H. K. Roy, I. Szleifer, and V. Backman | “Disordered chromatin packing regulates phenotypic plasticity”, Science Advances 6(2) doi: 10.1126/sciadv.aax6232 (2020). | 2020 |
| A.R. Shim, R. Nap, L. Almassalha, H. Matsuda, V. Backman and I. Szleifer | “Dynamic crowding regulates transcription”, Biophysical Journal, doi: https://doi.org/10.1016/j.bpj.2019.11.007. (2019). | 2019 |
| G. Spicer, A. Eid, D. Wangpraseurt, T. Swain, J. Winkelmann, J. Yi, M. Kuhl, L. Marcelino, V. Backman | “Measuring light scattering and absorption in corals with Inverse Spectroscopic Optical Coherence Tomography (ISOCT): a new tool for non-invasive monitoring”, Scientific Reports, 9:14148 doi: 10.1038/s41598-019-50658-3 (2019). | 2019 |
| X. Zhou, S. Gladstein, L. Almassalha, Y. Li, A. Eshein, L. Cherkezyan, P. Viswanathan, H. Subramanian, I. Szleifer, and V. Backman | "Preservation of cellular nano-architecture by the process of chemical fixation for nanopathology", PLOS One, 14(7) doi:10.1371/journal.pone.0219006. (2019). | 2019 |
| A. Stephens, P. Liu, V. Kandula, H. Chen, L. Almassalha, C. Herman, V. Backman, T. O’Halloran, S. Adam, R. Goldman, E. Banigan, J. Marko | "Physicochemical mechanotransduction alters nuclear shape and mechanics via heterochromatin formation", Molecular Biology of the Cell, doi:10.1091/mbc.E19-05-0286-T (2019). | 2019 |
| J.A. Winkelmann, G. Spicer, A. Eid, L.M. Almassalha, T.Q. Nguyen, V. Backman | "Spectral contrast optical coherence tomography angiography enables single-scan vessel imaging”, Light: Science and Applications, 8(7) doi: 10.1038/s41377-018-0117-7 (2019). | 2019 |
| S. Gladstein, L.M. Almassalha, L. Cherkezyan, J.E. Chandler, A. Eshein, A. Eid, D. Zhang, W. Wu, G.M. Bauer, A.D. Stephens, S. Morochnik, H. Subramanian, J.F. Marko, G.A. Ameer, I. Szleifer, V. Backman | “Multimodal interference-based imaging of nanoscale structure and macromolecular motion uncovers UV induced cellular paroxysm” Nature Communications, 10(1) 1652 (2019). | 2019 |
| A. Eshein, Y. Li, B. Dong, L. Almassalha, J. Chandler, T.Q. Nguyen, K. Hujsak, V. Dravid, C. Sun, H.F. Zhang and V. Backman | “Sub-10nm imaging of nucleic acids using spectroscopic intrinsic-contrast photon-localization optical nanoscopy (SICLON)” Optics Letters, 43(23) 5817-5820 (2018). | 2018 |
| S. Gladstein, D. Damania, L.T. Smith, V. Gupta, H. Subramanian, D.K. Rex, H.K. Roy, and V. Backman | “Correlating colorectal cancer risk with field carcinogenesis” Cancer Medicine, 10.1002/cam4.1357 (2018). | 2018 |
| R. Liu, J.A. Winkelmann, G. Spicer, Y. Zhu, A. Eid, G.A. Ameer, V. Backman, and J. Yi | “Single capillary oximetry and pericapillary ultrastructural sensing by dual-band dual-scan inverse spectroscopic optical coherence tomography” Light: Science and Applications, 7(57) DOI 10.1038/s41377-018-0057-2 (2018). | 2018 |
| S. Ruderman, A. Eshein, V. Valuckaite, U. Dougherty, A. Almograbi, A. Gomes, A. Singh, B. Pabla, H.K. Roy, J. Hart, M. Bissonnette, V. Konda, and V. Backman | “Early increase in blood supply (EIBS) is associated with tumor risk in the azoxymethane model of colon cancer” BMC Cancer, 18(1):814 (2018). PMC6090821 | 2018 |
| A. Eshein, A. Radosevich, B. Gould, W. Wu, V. Konda, L. Yang, A. Koons, S. Feder, V. Valuckaite, H. Roy, V. Backman and T. Q. Nguyen | “Fully automated fiber based optical spectroscopy system for use in a clinical setting” JBO, 23(7) 1-10 (2018). | 2018 |
| J. Winkelmann, A. Eid, T.Q. Nguyen, T. Bui, J. Yi, and V. Backman | “In Vivo broad-band visible light optical coherence tomography probe enables inverse spectroscopic analysis” Optics Letters, 43(3) 619-622 (2018) | 2018 |
| R. Kalman, A. Stawarz, D. Nunes, D. Zhang, M. Delacruz, R. Wali, H. Subramanian, V. Backman, H.K. Roy | “Biophotonic detection of high order chromatin alterations in field carcinogenesis predicts risk of future hepatocellular carcinoma: a pilot study” PLOS One, 13(5):e0197427 (2018). PMC5957524 | 2018 |
| S. Datta, R.M Sherva, M. De La Cruz, M.T. Long, P. Roy, V. Backman, S. Chowdhury and H.K. Roy | “Single nucleotide polymorphism facilitated downregulation of the cohesin stromal antigen-1: implications for colorectal cancer racial disparities" Neoplasia, 20(3) 289-294 (2018). PMC5883624 | 2018 |
| T.D. Swain, S. Lax, N. Lake, H. Grooms, V. Backman, L. Marcelino | “Relating coral skeletal structures at different length scales to growth, light availability to Symbiodinium, and thermal bleaching" Frontiers in Marine Science, 5:450. doi: 10.3389/fmars.2018.00450 (2018). | 2018 |
| A.D. Stephens, P. Liu, D. Banigan, L. Almassalha, V. Backman, S. Adam, R. Goldman and J. Marko | “Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins”, Molecular Biology of the Cell, 29(2) 220-233 (2018). | 2018 |
| T.D. Swain, E.C. Bold, P.C. Osborn, A.H. Baird, M.W. Westneat, V. Backman, and L.A. Marcelino | “Physiological integration of coral colonies is correlated with bleaching resistance”, Marine Ecology Progress Series, 586 1-10 (2018) (Feature article). | 2018 |
| G.L.C. Spicer, L. Almassalha, I.A. Martinez, R. Ellis, J. Chandler, S. Gladstein, D. Zhang, T.Q. Nugyen, S. Feder, H. Subramanian, R. de la Rica, S.A. Thompson, V. Backman | “Label free localization of nanoparticles in live cancer cells using spectroscopic microscopy", Nanoscale, 10(40) 19125-19130 (2018). | 2018 |
| R. Liu, W. Song, V. Backman, J. Yi | “Quantitative quality-control metrics for in vivo oximetry in small vessels by visible light optical coherence tomography angiography", Biomedical Optics Express 10(2) 465-486 (2018). | 2018 |
| L.M. Almassalha, G.M. Bauer, W. Wu, L. Cherkezyan, D. Zhang, A. Kendra, S. Gladstein, J.E. Chandler, D. VanDerway, B. Seagle, A. Ugolkov, D.D. Billadeau, T.V. O’Halloran, A.P. Mazar, H.K. Roy, I. Szleifer, S. Shahabi, and V. Backman | “Macrogenomic engineering via modulation of the scaling of chromatin packing density”, Nature Biomedical Engineering, doi: 10.1038/s41551-017-0153-2 (2017). PMC5809134 | 2017 |
| Y. Li, L.M. Almassalha, J.E. Chandler, X. Zhou, Y.E. Stypula-Cyrus, K.A. Hujsak, E.W. Roth, R. Bleher, H. Subramanian, I. Szleifer, V.P. Dravid, V. Backman | “The effects of chemical fixation on the cellular nanostructure”, Experimental Cell Research, 358(2), 253- 259 (2017). PMC5726765 | 2017 |
| B. Dong, B. Soetikno, X. Chen, V. Backman, C. Sun, H. Zhang | “Parallel three-dimensional tracking of quantum rods using polarization-sensitive spectroscopic photon localization microscopy”, ACS Photonics, 4(7), 1747-1752 (2017). | 2017 |
| D.A. Drew, S.M. Chin, K.K. Gilpin, M. Parziale, E. Pond, M.M. Schuck, K. Stewart, M. Flagg, C.A. Rawlings, V. Backman, P.J. Carolan, D.C. Chung, F.P. Colizzo III, M. Freedman, M. Gala, J.J. Garber, C. Huttenhower, D. Kedrin, H. Khalil, D.S. Kwon, S.D. Markowitz, G.L. Milne, N.S. Nishioka, J.M Richter, H.K. Roy, K. Staller, M. Wang, A.T. Chan | “Aspirin intervention for the reduction of colorectal cancer risk (ASPIRED) a study protocol for a randomized controlled trial”, Trials, 18(50) doi: 10.1186/s13063-016-1744-z (2017). PMC5286828 | 2017 |
| Y. Li, D. Zhang, I. Capoglu, D. Damania, K. Hujsak, L. Cherkezyan, E. Roth, R. Bleher, H. Wu, H. Subramanian, V.P. Dravid, V. Backman | “Measuring the autocorrelation function of nanoscale three-dimensional mass-density distribution in individual cells using scanning transmission electron microscopy”, Microscopy and Microanalysis, 23(3), 661-667 (2017). PMC5790320 | 2017 |
| G.M. Bauer, Y. Stypula-Cyrus, H. Subramanian, L. Cherkezyan, P. Viswanathan, D. Zhang, R. Iyengar, S. Bagalkar, J. Derbas, T. Graff, S. Gladstein, L.M. Almassalha, J. E. Chandler, H.K. Roy, and V. Backman | “The Transformation of the Nuclear Nanoarchitecture in Human Field Carcinogenesis”, Future Science, doi: 10.4155/fsoa-2017-0027 (2017). PMC5583697
| 2017 |
| T.D. Swain, E. DuBois, S.J. Goldberg, V. Backman and L. Marcelino | “Bleaching response of coral species in the context of assemblage response”, Coral Reefs, 36(2) 395-400 (2017). PMC5679474
| 2017 |
| P. Pradhan, D.J. Park, I. Capoglu, H. Subramanian, D. Damania, L. Cherkezyan, A. Taflove and V. Backman | “Reflection statistics of weakly disordered optical medium when its mean refractive index is different from an outside medium”, Optics Communications, 393, 185-190 (2017). | 2017 |
| R. Liu, G. Spicer, S. Chen, H.F. Zhang, J. Yi, and V. Backman | “A theoretical model for optical oximetry at the capillary level: exploring hemoglobin oxygen saturation through backscattering of single red blood cells”, JBO, 22(2), 025002 (2017). PMC5290596 | 2017 |
| M. DeLaCruz, S. Ledbetter, X. Sanjib, A. Tiwari, N. Momi, R. Wali, C. Bliss, C. Huang, D. Lichtenstein, S. Bhattacharya, A. Varma-Wilson, V. Backman, H.K. Roy | “Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis”, Oncotarget, 8(13), 20543-20557 (2017). PMC5400525. | 2017 |
| B. Dong, L. Almassalha, B.T. Soetikno, J.E. Chandler, T.Q. Nguyen, B.E. Urban, C. Sun, H.F. Zhang, and V. Backman | “Stochastic fluorescence switching of nucleic acids under visible light illumination”, Optics Express, 25(7), 7929-7944 (2017). PMC5810907 | 2017 |
| L. Cherkezyan, D. Zhang, H. Subramanian, A. Taflove, and V. Backman | “Review of interferometric spectroscopy of scattered light for the quantification of subdiffractional structure of biomaterials”, JBO, 22(3), 030901 (2017). PMC5348632 | 2017 |
| H.K. Roy, V. Turzhitsky, R. Wali, A.J. Radosevich, B. Jovanovic, G. DellaZanna, A. Umar, D.T. Rubin, M.J. Goldberg, L. Bianchi, M. De La Cruz, A. Bogojevic, I.R. Helenowski, L. Rodriguez, R. Chatterton, S. Skripkauskas, K. Page, C.R. Weber, X. Huang, E. Richmond, R.C. Bergan, V. Backman | “Spectral biomarkers for chemoprevention of colonic neoplasia: a placebo-controlled double-blinded trial with aspirin”, Gut, 66(2), 285-292 (2017). PMC5108693 | 2017 |
| L.M. Almassalha, A. Tiwari, P.T. Ruhoff, Y. Stypula-Cyrus, H. Matsuda, M.A. Dela Cruz, J.E. Chandler, C. White, C. Maneval, H. Subramanian, I. Szleifer, H. Roy, and V. Backman | “The global relationship between chromatin physical topology, fractal structure, and gene expression”, Scientific Reports, 7, 41061 (2017). PMC5259786 | 2017 |
| R.K. Wali, N. Momi, M. Dela Cruz, A.H. Calderwood, Y. Stypula-Cyrus, L. Almassalha, A. Chhaparia, C.R. Weber, A. Radosevich, A.K. Tiwari, B. Latif, V. Backman and H.K. Roy | “Higher-order chromatin modulator cohesion SA1 is an early biomarker for colon carcinogenesis: race-specific implications”, Cancer Prevention Research, DOI: 10.1158/1940-6207.CAPR-16-0054 (2016). PMC5093027 | 2016 |
| J. Yi, Z. Puyang, L. Feng, L. Duan, P. Liang, V. Backman, X. Liu, and H. Zhang | “Optical detection of early damages in retinal ganglion cells in a mouse model of partial optic nerve crush injury”, IOVS, 57(13) 5665-5671 (2016). PMC5089219 | 2016 |
| G. Spicer, S. Azarin, J. Yi, S. Young, R. Ellis, G. Bauer, L. Shea, and V. Backman | “Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography”, Phys Med Biol. 61(19) 6892-6904 (2016). PMC5056859 | 2016 |
| W. Wu, A.J. Radosevich, A. Eshein, T.Q. Nguyen, J. Yi, L. Cherkezyan, H.K. Roy, I. Szleifer, V. Backman | “Using electron microscopy to calculate optical properties of biological samples”, Biomedical Optics Express 7(11), 4749-4762 (2016). PMC5119613 | 2016 |
| L.M. Almassalha, G.M. Bauer, J. Chandler, S. Gladstein, L. Cherkezyan, Y. Stypula-Cyrus, S. Weinberg, D. Zhang, P. Thusgaard Ruhoff, H. Roy, H. Subramanian, N. Chandel, I. Szleifer, V. Backman | “Label-free imaging of the native, living cellular nano-architecture using partial-wave spectroscopic microscopy”, PNAS, 113(42) E6372-E6381 (2016). PMC5081614 | 2016 |
| T.D. Swain, J. Chandler, V. Backman, & L. Marcelino | “Consensus thermotolerance ranking for 110 Symbiodinium phylotypes: an exemplar utilization of a novel iterative partial-rank aggregation tool with broad application potential”, Functional Ecology 31, 172-183 (2016). | 2016 |
| T. Swain, J. Vega-Perkins, W. Oestreich, C. Triebold, E. DuBois, J. Henss, A. Baird, M. Siple, V. Backman, and L. Marcelino | “Coral bleaching response index: a new tool to standardize and compare susceptibility to thermal bleaching”, Global Change Biology, 22(7) 2475-88 (2016). PMC5433437 | 2016 |
| S.S. Rao, G.G Bushnell, S.M. Azarin, G. Spicer, B.A. Aguado, J.R. Stoehr, E.J. Jiang, V. Backman, L.D. Shea, & J.S. Jeruss | “Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo”, Cancer Research 76, 5209-5218 (2016). PMC5027988 | 2016 |
| H. Subramanian, P. Viswanathan, L. Cherkezyan, R. Iyengar, S. Rozhok, M. Verleye, J. Derbas, J. Czarnecki, H.K. Roy, V. Backman | “Procedures for risk-stratification of lung cancer using buccal nanocytology”, Biomedical Optics Express, 7(9) 3795-3810 (2016). PMC5030050 | 2016 |
| B.E. Urban, B. Dong, V. Backman, C. Sun, H.F. Zhang | “Subsurface super-resolution imaging of unstained polymer nanostructures”, Scientific Reports, 6, 28156; doi: 10.1038/srep28156 (2016). PMC4926209 | 2016 |
| D. Zhang, I. Capoglu, Y. Li, L. Cherkezyan, J. Chandler, G. Spicer, H. Subramanian, A. Taflove, and V. Backman | “FDTD-based optical microscopy simulation of dispersive media facilitates the development of optical imaging techniques”, JBO, 21(6): 65004 doi:10.1117/1.JBO.21.6.065004 (2016). PMC4901185 | 2016 |
| B. Dong, L. Almassalha, Y. Stypula-Cyrus, B.E. Urban, T.Q. Nguyen, C. Sun, H.F. Zhang, and V. Backman | “Super-resolution intrinsic fluorescence imaging of chromatin using native, unmodified nucleic acids for contrast”, PNAS, 113(35), 9716-9721 (2016). PMC5024634 | 2016 |
| J.E. Chandler, Y. Stypula-Cyrus, L. Almassalha, G. Bauer, L. Bowen, H. Subramanian, I. Szleifer, and V. Backman | “Colocalization of cellular nanostructure using confocal fluorescence and partial wave spectroscopy”, Journal of Biophotonics, 10(3), 377-384 (2016). PMC5112146 | 2016 |
| P. Pradhan, D.J. Park, I. Capoglu, H. Subramanian, D. Damania, L. Cherkezyan, A. Taflove, and V. Backman | “Enhancing the sensitivity of mesoscopic light reflection statistics in weakly disordered media by interface reflections”, International Journal of Modern Physics B, 30(23), 1650155 (2016). PMC5754019 | 2016 |
| L.M. Almassalha, G.M. Bauer, J. Chandler, S. Gladstein, I. Szleifer, H.K. Roy, and V. Backman | “The greater genomic landscape: the heterogeneous evolution of cancer”, Cancer Research, 76(19), 5605-9 (2016). PMC5084919 | 2016 |
| B. Dong, L. Almassalha, B.E. Urban, T.Q. Nguyen, S. Khuon, T.L. Chew, V. Backman, C. Sun, H.F. Zhang | “Super-resolution spectroscopic microscopy via photon localization”, Nature Communications, 7:12290 doi: 10.1038/ncomms12290 (2016). PMC4962472 | 2016 |
| J. Chandler, L. Cherkezyan, H. Subramanian, V. Backman | “Nanoscale refractive index fluctuations detected via sparse spectral microscopy”, Biomedical Optics Express, 7(3), 883-893 (2016). PMC4866463 | 2016 |
| T.D. Swain, E. DuBois, A. Gomes, V.P. Stoyneva, A.J. Radosevich, J. Henss, M.E. Wagner, E. Velazquez, J. Traub, B.J. Kennedy, C.M. Janczak, A.A. Grigorescu, M.W. Westneat, K. Sanborn, S. Levine, M. Schick, G. Parsons, J.D. Rogers, V. Backman, L.A. Marcelino | “Skeletal light scattering accelerates bleaching response in reef-building corals”, BMC Ecol., 16(1) (2016). PMC4800776 | 2016 |
| Q. Miao, J. Derbas, A. Eid, H. Subramanian, V. Backman | “Automated cell selection using support vector machine for application to spectral nanocytology”, BioMed Research International, 2016(3), 1-10 doi:10.1155/2016/6090912 (2016). PMC4745312 | 2016 |
| L. Cherkezyan, D. Zhang, H. Subramanian, A. Taflove, V. Backman, “Reconstruction of explicit structural properties at the nanoscale via spectroscopic microscopy | “Reconstruction of explicit structural properties at the nanoscale via spectroscopic microscopy”, JBO, 21(2), 025007 (2016). PMC4756051 | 2016 |
| D. Zhang, L. Cherkezyan, I. Capoglu, H. Subramanian, J. Chandler, S. Thompson, A. Taflove, V. Backman | “Spectroscopic microscopy quantifies the statistics of subdiffractional refractive index fluctuations in media with random rough surfaces”, Optics Letters, 40(21), 4931-4934 (2015). PMC4868404 | 2015 |
| J. Yi, Y. Stypula-Cyrus, C.S. Blaha, H.K. Roy, V. Backman | “Fractal characterization of chromatin decompaction in live cells”, Biophysical Journal, 109(11), 2218-2226 (2015). PMC4675813 | 2015 |
| N. Momi, V. Backman, C. Brendler, H.K. Roy | “Harnessing novel modalities: field carcinogenesis detection for personalizing prostate cancer management”, Future Oncology, 11, 2737-41 (2015). PMC4868392 | 2015 |
| B.E. Urban, B. Dong, Z. Zhang, V. Backman, C. Sun, H.F. Zhang | “Super-resolution two-photon microscopy via scanning patterned illumination”, Physical Review E, 91(4):042703 (2015). PMC4565794 | 2015 |
| A.J. Radosevich, N.N. Mutyal, A. Eshein, T.Q. Nguyen, B. Gould, J. Rogers, M. Goldberg, L. Bianchi, V. Konda, D. Rex, E. Yen, J. Van Dam, H.K. Roy, V. Backman | “Rectal optical markers for in vivo risk stratification of premalignant colorectal lesions”, Clinical Cancer Research, 21(19), 4337-55 (2015). PMC4592390 | 2015 |
| X. Wang, R. Bleher, V. Backman, G. Shekhawat, V. Dravid | “Comparison of sample preparation methods for analysis of mucus-secreting colon cancer cells by scanning electron microscopy”, Microscopy and Microanalysis, 21(3), 185-6 (2015) | 2015 |
| J. Yi, W. Liu, S. Chen, N. Sheibani, C.M. Sorenson, A.A. Fawzi, V. Backman, R.A. Linsenmeier, H.F. Zhang | “Visible-light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation”, Light: Science and Application, 4, e334 (2015). PMC4674267 | 2015 |
| A.J. Radosevich, A. Eshein, T.Q. Nguyen, V. Backman | “Subdiffusion reflectance spectroscopy to measure tissue ultrastructure and microvasculature: model and inverse algorithm”, JBO, 20(9):97002 (2015). PMC4963470 | 2015 |
| S.M. Azarin, J. Yi, R.M. Gower, B.A. Aguado, M.E. Sullivan, A.G. Goodman, E.J. Jiang, S.S. Rao, Y. Ren, V. Backman, J.S. Jeruss, L. Shea | “In vivo capture and label-free detection of early metastatic cells”, Nature Communications, 6:8094 (2015). PMC4563812 | 2015 |
| S. Chen, J. Yi, W. Liu, V. Backman, H. Zhang | “Monte Carlo investigation of optical coherence tomography retinal oximetry”, IEEE TBME, 62(9), 2308-2315 (2015). PMC4783381 | 2015 |
| B.D. Jovanovic, H. Subramanian, I.B. Helenowski, H.K. Roy, V. Backman | “Clinical trial laboratory data nested within subject: components of variance, sample size and cost”, Biometrics & Biostatistics International Journal, 2(2):00029 (2015). PMC4596537 | 2015 |
| N.N. Mutyal, A.J. Radosevich, S. Bajaj, V. Konda, U.D. Siddiqui, I. Waxman, M.J. Goldberg, J.D. Rogers, B. Gould, A. Eshein, S. Upadhye, A. Koons, M. Gonzalez, H.K. Roy, V. Backman | “In vivo risk analysis of pancreatic cancer through optical characterization of duodenal mucosa”, Pancreas, 44(5), 735-741 (2015). PMC4464933 | 2015 |
| H.K. Roy, C. Brendler, H. Subramanian, D. Zhang, C. Maneval, J. Chandler, K. Kaul, B. Helfand, C. Wang, M. Quinn, J. Petkewicz, M. Paterakos, V. Backman | “Nanocytological field carcinogenesis detection to mitigate overdiagnosis of prostate cancer: a proof of concept study”, PLoS One, 10(2): e0115999 (2015). PMC4338151 | 2015 |
| M. Dela Cruz, R.K. Wali, L.K. Bianchi, A.J. Radosevich, S.E. Crawford, L. Jepeal, M.J. Goldberg, J. Weinstein, N. Momi, P. Roy, A.H. Calderwood, V. Backman, H.K. Roy | “Colonic mucosal fatty acid synthase as an early biomarker for colorectal neoplasia: modulation by obesity and gender”, Cancer Epidemiology, Biomarkers & Prevention, 23(11), 2413-2421 (2014). PMC4470400 | 2014 |
| A. Doronin, A.J. Radosevich, V. Backman, I. Meglinski | “Two electric field Monte Carlo models of coherent back scattering of polarized light”, Journal of the Optical Society of America, 31(11), 2394-2400 (2014) | 2014 |
| A.J. Radosevich, N.N. Mutyal, J.D. Rogers, B. Gould, T.A. Hensing, D. Ray, V. Backman | “Buccal spectral markers for lung cancer risk stratification”, PLoS One, 9(10): e110157 (2014). PMC4192585 | 2014 |
| M. Patel, A. Gomes, S. Ruderman, D. Hardee, S. Crespo, M. Raimondo, T. Woodward, V. Backman, H.K. Roy, M. Wallace | “Polarization gating spectroscopy of normal-appearing duodenal mucosa to detect pancreas cancer”, Gastrointestinal Endoscopy, 80(5), 786-793 (2014). PMC4241379 | 2014 |
| R. K. Wali, T. A. Hensing, D. W. Ray, M. Dela Cruz, A. Tiwari, A. Radosevich, L. Jepeal, H.C. Fernando, V. Litle, M. Charlot, N. Momi, V. Backman, H.K. Roy | “Buccal microRNA dysregulation in lung field carcinogenesis: gender-specific implications”, International Journal of Oncology, 45(3), 1209-1215 (2014). PMC4144027 | 2014 |
| J. Yi, S. Chen, V. Backman, H.F. Zhang | “In vivo functional microangiography by visible-light optical coherence tomography”, Biomedical Optics Express, 5(10), 3603-3612 (2014). PMC4206328 | 2014 |
| L. Cherkezyan, H. Subramanian, V. Backman | “What structural length-scales can be detected by the spectral variance of a microscope image?”, Optics Letters, 39(15), 4290-4293 (2014). PMC4317340 | 2014 |
| Y. Stypula-Cyrus, N.N. Mutyal, M.A. Dela Cruz, D.P. Kunte, A.J. Radosevich, R.K.Wali, H.K. Roy, V. Backman | “End-binding protein 1 (EB1) up-regulation is an early event in colorectal carcinogenesis”, FEBS Letters, 5(3), 829-835 (2014). PMC4103177 | 2014 |
| H. Matsuda, G.G. Putzel, V. Backman, I. Szleifer | “Macromolecular crowding as a regulator of gene transcription”, Biophysical Journal, 106, 1801-1810 (2014). PMC4008821 | 2014 |
| J. Yi, A.J. Radosevich, Y. Stypula, N. Mutyal, S.M. Azarin, E.L. Horcher, M. Goldberg, L. Bianchi, S. Bajaj, H.K. Roy, V. Backman | “Spatially-resolved optical and ultra-structural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography”, JBO, 19(3), 036013 (2014). PMC4019430 | 2014 |
| L. Cherkezyan, Y. Stypula-Cyrus, H. Subramanian, C. White, M. Dela Cruz, R.K. Wali, M.J. Goldberg, L.K. Bianchi, H.K. Roy, V. Backman | “Nanoscale changes in chromatin organization represent the initial steps of tumorigenesis: a transmission electron microscopy study”, Biomed Central Cancer, 14(189), (2014). PMC3995586 | 2014 |
| A. Gomes, V. Backman | “Monte Carlo model of the depolarization of backscattered linearly polarized light in the sub-diffusion regime”, Optics Express, 22(5), 5325-5340 (2014) | 2014 |
| K. Phillips, D. Damania, H. Subramanian, V. Backman, E. Anderson, M.H. Wong, O. McCarty | “Network signatures of nuclear and cytoplasmic density alterations in a model of pre- and post-metastatic colorectal cancer”, JBO, 19(1), 016016 (2014). PMC4019418 | 2014 |
| J.D. Rogers, A.J. Radosevich, J. Yi, V. Backman | “Modeling light scattering in tissue as continuous random media using a versatile refractive index correlation function”, IEEE JSTQE, 20(02) 7000514 (2013). PMC4289622 | 2013 |
| J. Chandler, H. Subramanian, C.D. Maneval, C.A. White, V. Backman | “High-speed spectral nanocytology for early cancer screening”, J. Biomedical Optics, 18(11), 117002 (2013). PMC3817856 | 2013 |
| V. Konda, L. Cherkezyan, H. Subramanian, K. Wroblewski, D. Damania, V. Becker, M. Goldberg, J. Chennat, L. Karl, M. Ferguson, I. Waxman, H. Roy, V. Backman | “Nanoscale markers of esophageal field carcinogenesis: potential implications for esophageal cancer screening”, Endoscopy, 45, 983-988, (2013). PMC4195538 | 2013 |
| S. Ruderman, S. Mueller, A. Gomes, J. Rogers, V. Backman | “Method of detecting tissue contact for fiber-optic probes to automate data acquisition without hardware modification”, Biomedical Optics Express, 4(8), 1401-1412 (2013). PMC3756576 | 2013 |
| J. Yi, Q. Wei, W. Liu, V. Backman, H. Zhang | “Visible-light optical coherence tomography for retinal oximetry”, Optics Letters, 38(11), 1796-1798 (2013). PMC3986589 | 2013 |
| H.K. Roy, D.P. Damania, M. DelaCruz, D.P. Kunte, H. Subramanian, S.E.Crawford, A.K. Tiwari, R.K. Wali, V. Backman | “Nano-architectural alterations in mucus layer fecal colonocytes in field carcinogenesis: potential for screening”, Cancer Prevention Research, 6, 1111-1119 (2013). PMC387374 | 2013 |
| A.J. Radosevich, N.N. Mutyal, J. Yi, Y. Stypula-Cyrus, J.D. Rogers, M.J. Goldberg, L.K. Bianchi, S. Bajaj, H.K. Roy, V. Backman | “Ultrastructural alterations in field carcinogenesis measured by enhanced backscattering spectroscopy”, JBO, 18(9), 0970021-09700211 (2013). PMC3764252 | 2013 |
| I.R. Capoglu, J.D. Rogers, A. Taflove, V. Backman | “The microscope in a computer: Image synthesis from three-dimensional full-vector solutions of Maxwell’s equations at the nanometer scale”, Progress in Optics, 57, 1-91 (2013) | 2013 |
| T. Tan, A. Taflove, V. Backman | “Single realization stochastic FDTD for weak scattering waves in biological random media”, IEEE Trans. Ant. Prop., 61(2), 818-828 (2013). PMC4856227 | 2013 |
| I. Capoglu, A. Taflove, V. Backman | “Computation of tightly-focused laser beams in the FDTD method”, Optics Express, 21(1), 87-101 (2013). PMC3636759 | 2013 |
| I. Avital, R.C. Langan, T.A. Summers, S.R. Steele, S.A. Waldman, V. Backman, J. Yee, A. Nissan, P. Young, C. Womeldorph, P. Mancuso, R. Mueller, K. Noto, W. Grundfest, A.J. Bilchik, Mladjan Protic, M. Daumer, J. Eberhardt, Y.G. Man, B. LDM Brucher, A. Stojadinovic | “Evidence-based guidelines for precision risk stratification-based screening (PRSBS) for colorectal cancer: lessons learned from the US armed forces: consensus and future directions”, Journal of Cancer, 4(3), 172-192 (2013). PMC3584831 | 2013 |
| V. Backman, H.K. Roy | “Advances in biophotonics detection of field carcinogenesis for colon cancer risk stratification”, Journal of Cancer, 4(3), 251-261 (2013) (Special issue, invited paper). PMC3584838 | 2013 |
| J. Yi, A.J. Radosevich, J.D. Rogers, S.C.P. Norris, I.R. Capoglu, A. Taflove, V. Backman | “Can OCT be sensitive to nanoscale structural alterations in biological tissue?”, Optics Express, 21(7) 9043–9059 (2013). PMC3641881 | 2013 |
| N.N. Mutyal, A. Radosevich, A. Tiwari, Y. Stypula, R. Wali, V. Turzhitsky, J.D. Rogers, H.K. Roy ,V. Backman | “Biological mechanisms underlying structural changes induced by colorectal field carcinogenesis measured with Low-Coherence Enhanced Backscattering Spectroscopy (LEBS)”, PLoS One, 8(2), e57206 (2013). PMC3576387 | 2013 |
| A. Gomes, V. Backman | “An algorithm for automated selection of application-specific fiber-optic reflectance probes”, J. Biomedical Optics, 18(2), 0270121-02701212 (2013). PMC3585420 | 2013 |
| D. Damania, H.K. Roy, D. Kunte, J.A. Hurteau, H. Subramanian, L. Cherkezyan, M. Shah, N. Krosnjar, V. Backman | “Insights into the field carcinogenesis of ovarian cancer based on the nanocytology of endocervical and endometrial epithelial cancer cells”, International Journal of Cancer, 133(5), 1143-1152 (2013). PMC3695064 | 2013 |
| L.A. Marcelino, M.W. Westneat, V. Stoyneva, J. Henss, J.D. Rogers, A. Radosevich, V. Turzhitsky, M. Siple, A. Fang, T.D. Swain, J. Fung, V. Backman | “Modulation of light-enhancement to symbiotic algae by light-scattering in corals and evolutionary trends in bleaching”, PLoS One, 8(4) e61492 (2013). PMC3632607 | 2013 |
| The Physical Sciences-Oncology Centers Network | “A physical sciences network characterization of non-tumorigenic and metastatic cells”, Sci. Rep. 3, 1449; DOI:10.1038/srep01449 (2013). PMC3636513 | 2013 |
| Y. Stypula-Cyrus, D. Damania, D.P. Kunte, M. De La Cruz, H. Subramanian, H.K. Roy, V. Backman | “HDAC up-regulation in early colon field carcinogenesis is involved in cell tumorigenicity through regulation of chromatin structure”, PLoS One, 8(5): e64600 (2013). PMC3665824 | 2013 |
| L. Cherkezyan, I. Capoglu, H. Subramanian, J.D. Rogers, D. Damania, A. Taflove, V. Backman | “Interferometric spectroscopy of scattered light can quantify the statistics of subdifractional refractive-index fluctuations”, PRL, 111, 033903 (2013). PMC4123763 | 2013 |
| A.J. Gomes, V. Backman | “Analytical light reflectance models for overlapping-illumination and collection area geometries”, Applied Optics, 51(33), 8013-8021 (2012). PMC3655705. | 2012 |
| H.K. Roy, V. Backman | “Spectroscopic applications in gastrointestinal endoscopy”, Clinical Gastroenterology and Hepatology, 10(12), 1335-1341 (2012). PMC3756813 | 2012 |
| A.J. Radosevich, J. Yi, J.D. Rogers, V. Backman | “Structural length-scale sensitivities of diffuse reflectance in continuous random media under the Born approximation”, Optics Letters, 37(24), 5220-5222 (2012). PMC3655697 | 2012 |
| A.J. Radosevich, J.D. Rogers, I. Capoglu, N. Mutyal, P. Pradhan, V. Backman | “Structural length-scale sensitivities of diffuse reflectance in continuous random media under the Born approximation”, Optics Letters, 37(24), 5220-5222 (2012). PMC3655697 | 2012 |
| J. Yi, V. Backman | “Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography”, Optics Letters, 37(21), 4443-4445 (2012). PMC3640644 | 2012 |
| N. Mutyal, A. Radosevich, B. Gould, J.D. Rogers, A. Gomes, V. Turzhitsky, V. Backman | “A fiber optic probe design to measure depth-limited optical properties in vivo with Low-coherence Enhanced Backscattering (LEBS) Spectroscopy”, Optics Express, 20(18), 19643-19657 (2012). PMC3635466 | 2012 |
| S.D. Strasser, G. Shekhawat, J.D. Rogers, V.P. Dravid, A. Taflove, V. Backman | “Near-field penetrating optical microscopy: A live cell nanoscale refractive index measurement technique for quantification of internal macromolecular density”, Optics Letters, 37(4), 506-508 (2012), PMC3357211 | 2012 |
| A.J. Gomes, S. Ruderman, M. DelaCruz, R.K. Wali, H.K. Roy, V. Backman | “Errata: in vivo measurement of the shape of the tissue refractive index correlation function and its application to detection of colorectal field carcinogenesis”, J. Biomedical Optics, 17(4), 470051-470058 (2012). PMC3382344 | 2012 |
| D. Damania, H.K. Roy, H. Subramanian, M.J. Goldberg, D.S. Weinberg, J. Muldoon, L. Cherkezyan, Y. Zhu, L.K. Bianchi, D. Shah, P. Pradhan, M. Borkar, H. Lynch, V. Backman | “Nanocytology of rectal colonocytes to assess risk of colon cancer based on field cancerization”, Cancer Research, 72(11), 2720-2727 (2012). PMC3557939. | 2012 |
| J. Yi, Q. Wei, H.F. Zhang, V. Backman | “Structured interference optical coherence tomography”, Optics Letters, 37(15), 3048-3050 (2012). PMC3544536. | 2012 |
| A.J. Radosevich, J.D. Rogers, V. Turzhitsky, N.N. Mutyal, J. Yi, H.K. Roy, V. Backman | “Polarized Enhanced Backscattering Spectroscopy for Characterization of Biological Tissues at Subdiffusion Length-scales”, IEEE JSTQE, 18(4) 1313-1325 (2012) (invited paper). PMC3806115. | 2012 |
| L. Cherkezyan, H. Subramanian, V. Stoyneva, J. Rogers, S. Yang, D. Damania, A. Taflove, V. Backman | “Targeted alteration of real and imaginary refractive index of biological cells by histological staining”, Optics Letters, 37(10), 1601-1603 (2012), PMC3367326. | 2012 |
| I.R. Capoglu, A. Taflove, V. Backman | “A Frequency-Domain Near-Field-to-Far-Field Transform for Planar Layered Media”, IEEE Trans. of Antennas and Propagation, 60(4), 1878-1885 (2012). | 2012 |
| D.P. Kunte, M. De La Cruz, R.K. Wali, Y. Stypula, A.K. Tiwari, J. Brasky, T. Gibson, P. Subramaniyan, A. Menon, V. Backman, H.K. Roy | “Dysregulation of MicroRNAs in Early Colon Carcinogenesis: Implications for Screening”, PLoS One, (9)7, e45591 (2012). PMC3458063. | 2012 |
| A.J. Gomes, V. Turzhitsky, S. Ruderman, V. Backman | “Monte Carlo Model of the Penetration Depth for Polarization Gating Spectroscopy: Influence of Illumination-Collection Geometry and Sample Optical Properties”, J. Biomedical Optics, 51(20), 4627-4637 (2012). PMC3557942. | 2012 |
| A. Radosevich, N. Mutyal, V. Turzhitsky, J. Rogers, J. Yi, A. Taflove, V. Backman | “Measurement of the spatial backscattering impulse-response at short length-scales with polarized enhanced backscattering (EBS)”, Optics Letters, 36(24), 4737-4739 (2011), PMC3355761. | 2011 |
| V. Backman, H.K. Roy | “Light-scattering Technologies for Field Carcinogenesis Detection: A Modality for Endoscopic Pre-screening”, Gastroenterology, 140(1), 35-41 (2011). PMC3319699. | 2011 |
| H.K. Roy, M.J. Goldberg, S. Bajaj, V. Backman | “Colonoscopic Optical Biopsy: Bridging Technological Advances to Clinical Practice”, Gastroenterology, 140(7), 1863–1880 (2011) (invited editorial, cover article). PMC3557924. | 2011 |
| H.K. Roy, T. Hensing, V. Backman | “Nanocytology for field carcinogenesis detection: novel paradigm for lung cancer risk stratification”, Future Oncology, 7(11), 1-3 (2011) (editorial). PMC4123752. | 2011 |
| J.S. Kim, P. Pradhan, V. Backman, I. Szleifer | “Influence of chromosome density variations on the increase in nuclear disorder strength in carcinogenesis”, Physical Biology, 8(1), 015004, 1-6 (2011). | 2011 |
| P. Pradhan, D. Damania, H. Joshi, V. Turzhitsky, H. Subramanian, H.K. Roy, A. Taflove, V. Dravid, V. Backman | “Quantification of nanoscale density fluctuations by electron microscopy: probing cellular alterations in early carcinogenesis”, Physical Biology, 8, 026012, 1-9 (2011), PMC3332100. | 2011 |
| S. Yang, A. Taflove, V. Backman | “Experimental confirmation at visible Light wavelengths of the giant backscattering perturbation phenomenon of the photonic nanojet”, Physical Biology, 8, 026012, 1-9 (2011), PMC3332100. | 2011 |
| S.R. Gandhi, A.K. Tiwari, D.P. Kunte, M.A. De La Cruz, Y. Stypula, T. Gibson, J. Brasky, V. Backman, R.K. Wali, H.K. Roy | “Association of stem-like cells in gender-specific chemoprevention against intestinal neoplasia in MIN mouse”, Oncology Reports, 26(5), 1127-1132 (2011). PMC3557947. | 2011 |
| J.D. Rogers, V. Stoyneva, V. Turzhitsky, N. Mutyal, P. Pradhan, I.R. Capoglu, V. Backman | “An alternate formulation of enhanced backscattering as phase conjugation and diffraction: derivation and experimental observation”, Optics Express, 19(13), 11922-11931 (2011), PMC3319707. | 2011 |
| I.R. Capoglu, C.A. White, J.D. Rogers, A. Taflove, V. Backman | “Numerical Simulation of Partially-Coherent Broadband Optical Imaging Using the FDTD Method”, Optics Letters, 36(9), 1596-1598 (2011), PMC3319708. | 2011 |
| J.S. Kim, V. Backman, I. Szleifer | “Crowding-induced structural alterations of random-loop chromosome model”, Phys. Rev. Lett., 106, 168102, 1-4 (2011). | 2011 |
| A.K. Tiwari, S.E. Crawford, A. Radosevich, R. Wali, Y. Stypula, D.P. Kunte, N. Mutyal, S. Ruderman, A. Gomes, M.L. Cornwell, M. De La Cruz, J. Brasky, T. Ward, V. Backman, H. K. Roy | “Neo-Angiogenesis and the Premalignant Micro-Circulatory Augmentation of Early Colon Carcinogenesis”, Cancer Letters, 306, 205–213 (2011). PMC3569093. | 2011 |
| V. Turzhitsky, A. J. Radosevich, N. N. Mutyal, J. D. Rogers, V. Backman | “Measurement of Optical Scattering Properties with Low-Coherence Enhanced Backscattering Spectroscopy”, JBO, 16(6), 067007, 1-14 (2011), PMC3138801 | 2011 |
| V. Turzhitsky, N.N. Mutyal, A.J. Radosevich, V. Backman | “Multiple Scattering Model for the Penetration Depth of Low-coherence Enhanced Backscattering”, JBO, 16(9), 097006, 1-5 (2011) PMC3188644. | 2011 |
| H.K. Roy, H. Subramanian, D. Damania, T. Hensing, D. Ray, A. Bogojevic, P. Pradhan, J. Rogers, N. Hasabou, I. Capoglu, V. Backman | “Optical Detection of Buccal Epithelial Nano-Architectural Alterations in Patients Harboring Lung Cancer: Implications for Screening”, Cancer Research, 70(20), 7748-7754 (2010). PMC3703950. | 2010 |
| V. Turzhitsky, J.D. Rogers, N.N. Mutyal, H.K. Roy, V. Backman | “Characterization of light transport in scattering media at sub-diffusion length scales with Low-coherence Enhanced Backscattering”, IEEE JSTQE, 16(3), 619-626 (2010). PMC2964859. | 2010 |
| N.N. Boustany, S.A. Boppart, V. Backman | “Microscopic Imaging and Spectroscopy with Scattered Light”, Annual Review of Biomedical Engineering, 12, 285–314 (2010). PMC3357207. | 2010 |
| H.K. Roy, A.J. Gomes, S. Ruderman, V. Turzhitsky, J.D. Rogers, V. Stoyneva, L.K. Bianchi, M.J. Goldberg, Y.L. Kim, E. Yen, A. Kromine, M. Jameel, V. Backman | “Optical Measurement of Rectal Microvasculature as an Adjunct to Flexible Sigmoidosocopy: Gender-Specific Implications”, Cancer Prevention Research, 3(7), 844–851 (2010). PMC3418881. | 2010 |
| D. Damania, H. Subramanian, A.K. Tiwari, Y. Stypula, D. Kunte, P. Pradhan, H.K. Roy, V. Backman | “Role of cytoskeleton in controlling the disorder strength of cellular nanoscale architecture”, Biophys. J., 99, 989–996 (2010), PMC2913198. | 2010 |
