Bioengineered tissue model to study light transport in tissue

A wide array of optical techniques can currently be used for non-invasive analysis of biological tissue. These development and implementation of these techniques are based on understanding light transport in tissue. However, these studies have been impeded in part by the lack of realistic tissue models that can replicate both the morphological complexity and the optical properties of biological tissue. We have developed a novel bioengineered connective tissue model to study light transport in tissue. This tissue model was fabricated by combination of scaffolding and crosslinking techniques. The model was designed to have optical properties and microarchitecture very similar to those of a real connective tissue. Moreover, the physical and optical properties of the model can be easily and reproducibly controlled.

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Backman's Biophotonics Laboratory at Northwestern University

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